BI-847325 Collagen-Coated

BI-847325 Collagen-CoatedBI 847325 is an orally bioavailable, and selective dual MEK Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well as human MEK1 and MEK2, respectively. Phase 1.

inhibits protein tyrosine kinase (PTK) of epidermal growth factor receptor with IC50 values of 91

Alvespimycin (17-DMAG) HCl is a potent HSP90 inhibitor with IC50 of 62 nM in a cell-free assay

69 nM/37 nM/108 nM and 59 nM/65 nM in cell-free assays

Ipatasertib (GDC-0068) is a highly selective pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 5 nM/18 nM/8 nM in cell-free assays

used as spasmolytic agent for treatment of both acute and chronic abdominal pain

Sodium orthovanadate is an alkaline phosphatase and (Na

M in cell-free assays for HSP70

and induces luteolysis by direct action on the corpus luteum

inhibits autophagy and de novo lipidation of LC3 and leads to the stabilization of autophagy substrates

M for DNMT1

made by plants

>100-fold to VEGFR2