GSK3326595 (EPZ015938) Substrate

GSK3326595 (EPZ015938) SubstrateGSK3326595 (EPZ015938) is an orally active, potent and selective inhibitor of protein arginine methyltransferase 5 (PRMT5) and potently inhibits tumor growth in vitro and in vivo in animal models.

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Lixisenatide is a once-daily short-acting glucagon-like peptide-1 (GLP-1) receptor agonist (GLP-1RA) with an IC50 of 1

inhibiting DNA synthesis and cell division

Volasertib (BI 6727) is a highly potent Plk1 inhibitor with IC50 of 0

inactive for ZAP-70

Mildronate is an inhibitor of biosynthesis of L-carnitine by gamma-butyrobetaine (GBB) hydroxylase and as a competitive inhibitor of renal carnitine reabsorption

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and orally bioavailable adiponectin receptor agonist with KD of 1

GNE-9605 is a highly potent and selective leucine-rich repeat kinase 2 (LRRK2) inhibitor with Ki and IC50 of 2 nM and 19 nM

and selective P2X7 receptor antagonist with pIC50 of 6

ML390 is a human DHODH inhibitor with an IC50 of 0